The hepatic endoplasmic reticulum (ER)-anchored cytochromes P450 (P450s) are mixed-function oxidases engaged in the biotransformation of physiologically relevant endobiotics as well as of myriad xenobiotics of therapeutic Cardio Machines and environmental relevance.P450 ER-content and hence function is regulated by their coordinated hemoprotein syn
Several studies have correlated protein restriction associated with other nutritional deficiencies with the development of cardiovascular and renal diseases.The driving hypothesis for this study was that Ang II signaling pathways in the heart and kidney are affected by chronic protein, mineral and vitamin restriction.Wistar rats aged 90 days were f
Childhood obesity has emerged as a significant public health challenge, with profound consequences that negatively impact endocrine functions.Excess adiposity in children leads to dysregulation of various hormonal pathways, notably spoon insulin resistance and hyperinsulinemia, the best-established endocrine changes in obesity.If insulin resistance
Robbert JJ Gobbens,1–3 Roy Remmen3 1Faculty of Health, Sports and Social Work, Inholland University of Applied Sciences, Amsterdam, the Netherlands; 2Zonnehuisgroep Amstelland, Amstelveen, the Netherlands; 3Department of Primary and Interdisciplinary Care, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium Object
Newly identified material belonging to the holotype Door Closer specimen of Ianthodon schultzei substantially increases our knowledge of this poorly known basal sphenacodont synapsid from the fossil site in Garnett, Kansas (Missourian, Late Pennsylvanian).The original description, based on a partial dermal skull roof, is augmented with information